Perioperative medicine & outcomes
The effect of personalized perioperative blood pressure management on intraoperative cerebral oxygen saturation, burst suppression ratio and postoperative neurological outcomes in patients having major non-cardiac surgery: an observational substudy of the IMPROVE-pilot randomized controlled trial
Authors' conclusion
In this substudy of the IMPROVE-pilot trial, we observed no evidence of difference in intraoperative area under baseline rSO2 between patients who received personalized compared to routine perioperative blood pressure management.
Study context
- Population
- Patients aged ≥ 45 years, American Society of Anesthesiologists (ASA) II–IV, scheduled for elective major surgery49 analysed
- Participants
- 50 patients
- Comparison
- Personalized vs routine intraoperative BP management
- Primary endpoint
- Intraoperative rSO2 (area under baseline rSO2)
Methodological detailsprespecified exploratory substudy, observational substudy, 55 patients enrolled
- Prespecified exploratory substudy
- Observational substudy
- 55 patients enrolled
Primary result
As reported in the abstract
Area under baseline rSO2
- Median areas under baseline rSO2 similar between the two groups
Further findings
Events
| Outcome | Personalized | Routine |
|---|---|---|
| POD · first 3 postoperative days | 1 | 0 |
Area under baseline burst suppression ratio (BSR)
- Median areas under baseline BSR similar between the two groups
Delayed neurocognitive recovery (dNCR) · postoperative days 3, 7, and 30
- No meaningful difference in incidence between the groups
Original publication
The effect of personalized perioperative blood pressure management on intraoperative cerebral oxygen saturation, burst suppression ratio and postoperative neurological outcomes in patients having major non-cardiac surgery: an observational substudy of the IMPROVE-pilot randomized controlled trial. J Clin Monit Comput. Published 22 December 2025. doi:10.
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