Effect of pneumatic leg compression on phenylephrine dose for hypotension prophylaxis via variable rate infusion at cesarean delivery: an unblinded randomized controlled trial
Primary result · Phenylephrine dose per minuteResult — go to the resultMean difference −6.6 μg·min-1 95% CI −10.5 to −2.7Authors' conclusion
Intermittent pneumatic compression combined with a variable-rate phenylephrine infusion reduced the phenylephrine dose per minute and the incidence of hypotension during CD under spinal anesthesia.
Study context
- Population
- Healthy women undergoing elective cesarean delivery (CD) under combined spinal-epidural anaesthesia
- Participants
- 76 women
- Comparison
- Intermittent pneumatic compression (IPC) vs Control
- IPCn = 38
- Controln = 38reference
- Primary endpoint
- Dose of phenylephrine per minute
Methodological detailsunblinded
- Unblinded
Primary result
Phenylephrine dose per minute
Mean difference
−6.6 μg·min-1
95% CI −10.5 to −2.7
P = 0.001
By group
IPC vs Control
mean difference −6.6 μg·min-1 (95% CI −10.5 to −2.7); P = 0.001
As reported in the abstract
Further findings
Incidence of hypotension (SAP < 80% baseline)
P = 0.005
Mean, μg
| Outcome | IPC | Control | Mean difference (μg) (95% CI) | P value | |
|---|---|---|---|---|---|
| Total phenylephrine dose | 603.2 (SD 217.1) | 706.2 (SD 247.5) | −102.9 (−209.4 to 3.5) | P = 0.058 | |
| −300−200−1000100Difference, μg (linear scale) |
Safety
Maternal side effects and neonatal outcomes
- No significant differences between the two groups
Original publication
Effect of pneumatic leg compression on phenylephrine dose for hypotension prophylaxis via variable rate infusion at cesarean delivery: an unblinded randomized controlled trial. Int J Obstet Anesth. Published 11 June 2024. doi:10.
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