Optimal Infusion Rate of Norepinephrine for Prevention of Spinal Hypotension for Cesarean Delivery: A Randomized Controlled Trial, Using Up-Down Sequential Allocation
Authors' conclusion
Norepinephrine is more potent than phenylephrine by a factor of approximately 13 when administered as infusion for equivalent maternal blood pressure control.
Study context
- Population
- Healthy patients undergoing elective cesarean delivery with standardized spinal anesthesia
- Participants
- 60 patients
- Comparison
- Norepinephrine vs phenylephrine infusion
- Primary endpoint
- ED50 infusion rate to maintain maternal SBP within 20% of baseline after spinal anesthesia (Dixon-Massey), and relative potency ratio
Methodological detailsup-down sequential allocation, dose-finding
- Up-down sequential allocation
- Dose-finding
Primary result
ED50 infusion rate
Potency ratio
12.6
95% CI 9.92–15.9
By group
As reported in the abstract
Further findings
HR, stroke volume (SV) and cardiac output (CO)
- Did not differ between the groups
Original publication
Optimal Infusion Rate of Norepinephrine for Prevention of Spinal Hypotension for Cesarean Delivery: A Randomized Controlled Trial, Using Up-Down Sequential Allocation. Anesth Analg. Published 9 October 2024. doi:10.
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