Cardiac arrest & resuscitation
Effect of prehospital high-dose glucocorticoid on hemodynamics in patients resuscitated from out-of-hospital cardiac arrest: a sub-study of the STEROHCA trial
Primary resultResult — go to the resultMean difference - 0.04 mcg/kg/min 95% CI - 0.07 to - 0.01Authors' conclusion
Prehospital treatment with high-dose glucocorticoid was associated with reduced norepinephrine use in resuscitated OHCA patients.
Study context
- Population
- Resuscitated out-of-hospital cardiac arrest (OHCA) patients comatose at admission who survived until intensive care unit (ICU) admission
- Participants
- 114 participants
- Comparison
- Prehospital methylprednisolone 250 mg vs placebo
- Glucocorticoidn = 56
- Placebon = 58reference
- Primary endpoint
- Cumulated norepinephrine use (mcg/kg/min) from ICU admission
- Follow-up
- Up to 48 h
Methodological detailsplacebo-controlled, phase 2, sub-study
- Placebo-controlled
- Phase 2
- Sub-study
Primary result
As reported in the abstract
Mean difference
- 0.04 mcg/kg/min
95% CI - 0.07 to - 0.01
P = 0.02
Secondary outcomes
| Outcome | Estimate |
|---|---|
| MAP · 12-24 h post-admissionHigher MAP with glucocorticoid | mean differences 6 to 7 mmHg (95% CI from 1 to 12) |
| Vasoactive-inotropic score (VIS) · 12-24 h post-admissionLower VIS with glucocorticoid | mean differences - 4.2 to - 3.8 (95% CI from - 8.1 to 0.3) |
| VIS/MAP ratio · 12-24 h post-admissionLower VIS/MAP ratio with glucocorticoid | mean differences - 0.10 to - 0.07 (95% CI from - 0.16 to - 0.01) |
| Heart rate · 12-24 h post-admissionNo major differences | mean differences - 4 to - 3 (95% CI from - 11 to 3) |
- Mean arterial pressure (MAP): also present 30-48 h post-admission but to a smaller extent and with increased statistical uncertainty
- Vasoactive-inotropic score (VIS): also present 30-48 h post-admission but to a smaller extent and with increased statistical uncertainty
- VIS/MAP ratio: also present 30-48 h post-admission but to a smaller extent and with increased statistical uncertainty
Pulmonary artery catheter measurements
- No differences between groups
Outcomes at ICU admission
- No differences
Original publication
Effect of prehospital high-dose glucocorticoid on hemodynamics in patients resuscitated from out-of-hospital cardiac arrest: a sub-study of the STEROHCA trial. Crit Care. Published 22 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →