Cardiac arrest & resuscitation
Inflammatory response after prehospital high-dose glucocorticoid to patients resuscitated from out-of-hospital cardiac arrest: A sub-study of the STERoid for OHCA (STEROHCA) trial
Authors' conclusion
Administering high-dose glucocorticoid treatment promptly after resuscitation from OHCA influenced the inflammatory response with a reduction in several systemic proinflammatory cytokines after 24 h.
Study context
- Population
- Patients resuscitated from out-of-hospital cardiac arrest (OHCA)130 (95%) with ≥1 plasma sample
- Participants
- 137 patients
- Comparison
- Prehospital methylprednisolone 250 mg vs placebo
- Glucocorticoidn = 68
- Placebon = 69reference
- Primary endpoint
- Inflammatory response (pro- and anti-inflammatory cytokines in plasma)
- Follow-up
- 0, 24, 48 and 72 h post-admission
Methodological detailspredefined sub-study
- Predefined sub-study
Primary result
As reported in the abstract
Inflammatory markers, Glucocorticoid vs Placebo (ratio)
- IL-10 at admission
- ratio 2.74 (CI 1.49–5.05); P = 0.006
- IL-6 at 24 h
- ratio 0.06 (CI 0.03–0.10); P < 0.001
- IL-8 at 24 h
- ratio 0.53 (CI 0.38–0.75); P < 0.001
- MCP-1 at 24 h
- ratio 0.02 (CI 0.13–0.31); P < 0.001
- MIP-1b at 24 h
- ratio 0.28 (CI 0.18–0.45); P < 0.001
- TNF-α at 24 h
- ratio 0.6 (CI 0.4–0.8); P = 0.01
Further findings
Survival · 180 days
Original publication
Inflammatory response after prehospital high-dose glucocorticoid to patients resuscitated from out-of-hospital cardiac arrest: A sub-study of the STEROHCA trial. Resuscitation. Published 31 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →