Effect of vasoactive drugs used for management of hypotension during pregnancy on uterine hemodynamic parameters: a systematic review and meta-analysis of preclinical and clinical studies
Pooled resultResult — go to the resultSMD 0.66 95% CI 0.02–1.30Authors' conclusion
These findings suggest that vasoactive drugs do not improve uterine hemodynamics.
Study context
- Population
- Pregnant women and animals with hemochorial placentas receiving vasoactive drugs for hypotension12 clinical (368 patients), 21 preclinical (206 animals) studies
- Comparison
- Vasoactive drugs for hypotension in pregnancy: uterine hemodynamics before vs after administration
- Outcome
- Uterine hemodynamics (uterine blood flow or uterine resistance)
Methodological detailsbefore-after (impact) design in most studies, SMD meta-analysis, Risk of bias low to moderate in clinical studies; before-after design of preclinical studies inherently susceptible to bias
- Before-after (impact) design in most studies
- SMD meta-analysis
- Risk of bias low to moderate in clinical studies; before-after design of preclinical studies inherently susceptible to bias
Pooled result
As reported in the abstract
SMD
0.66
95% CI 0.02–1.30
Vasoactive drugs for hypotension in pregnancy: uterine hemodynamics before vs after administration
SMD 0.66 (95% CI 0.02–1.30)
Original publication
Effect of vasoactive drugs used for management of hypotension during pregnancy on uterine hemodynamic parameters: a systematic review and meta-analysis of preclinical and clinical studies. Int J Obstet Anesth. Published 19 October 2024. doi:10.
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