Effectiveness of Fludrocortisone Plus Hydrocortisone versus Hydrocortisone Alone in Septic Shock: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Authors' conclusion
In adult patients with septic shock, fludrocortisone plus hydrocortisone was associated with lower risk of all-cause mortality at last follow-up than placebo and hydrocortisone alone.
Study context
- Population
- Adults with septic shock
- Participants
- 7,688 adults · 17 trials
- Comparison
- Fludrocortisone plus hydrocortisone vs hydrocortisone alone vs placebo or usual care
- Outcome
- All-cause mortality at last follow-up
- Follow-up
- Last
Pooled result
As reported in the abstract
Relative risk (95% CrI)
Fludrocortisone plus hydrocortisone vs Placebo or usual careCrI; 98.3% probability of superiority, moderate-certainty evidence
0.85(0.72–0.99)
Hydrocortisone alone vs Placebo or usual careCrI; 73.1% probability of superiority, low-certainty evidence
0.97(0.87–1.07)
Fludrocortisone plus hydrocortisone vs Hydrocortisone aloneCrI; 94.2% probability of superiority, moderate-certainty evidence; based primarily on indirect evidence (only two trials with direct evidence)
0.88(0.74–1.03)
Original publication
Effectiveness of Fludrocortisone Plus Hydrocortisone versus Hydrocortisone Alone in Septic Shock: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. Am J Respir Crit Care Med. Published 15 May 2024. doi:10.
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