ICU sedation, delirium & recovery
Effectiveness of targeted post-acute interventions and follow-up services for sepsis survivors: a systematic review
Authors' conclusion
Post-acute interventions, such as care coordination, bundle approaches, and rehabilitation can improve patient-relevant outcomes in sepsis survivors.
Study context
- Population
- Sepsis survivors in high-income countries
- Participants
- 383,680 survivors · 14 studies
- Comparison
- Targeted post-acute interventions and follow-up services vs usual care
- Outcome
- Patient-relevant long-term outcomes
Methodological detailsRoB2 and ROBINS-I risk of bias assessment
- RoB2 and ROBINS-I risk of bias assessment
Pooled result
As reported in the abstract
- Rehabilitation associated with long-term survival benefit until 10 years after sepsis (3 observational studies)
- 8-week exercise-based intervention improved anaerobic threshold (1 RCT with minimization)
- Care coordination and follow-up bundles (n = 7) reduced rehospitalization and mortality until 12 months post-discharge; associated with improved long-term physical function and PTSD symptoms
- ICU-specific virtual reality-based intervention may reduce PTSD and depression symptoms up to 6 months
- Moderate risk of bias (non-randomised studies) or some concerns (RCTs)
Original publication
Effectiveness of targeted post-acute interventions and follow-up services for sepsis survivors: a systematic review. Crit Care. Published 8 August 2025. doi:10.
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