Respiratory failure & ventilation
The Cost-Effectiveness of Early Active Mobilization During Mechanical Ventilation in the ICU: An Economic Evaluation Alongside the Treatment of Mechanically Ventilated Adults With Early Activity and Mobilization (TEAM) Trial
Primary result · Incremental costsResult — go to the resultIncremental costs $1,823 95% CI -$10,552 to $12,027Authors' conclusion
Our trial-based analysis found no evidence that higher-dose early active mobilization is a cost-effective intervention compared with usual care mobilization for mechanically ventilated adult ICU patients; however, results from sensitivity analyses provided some evidence that it may be cost saving if one is willing to accept poorer outcomes.
Study context
- Population
- Adult ICU patients undergoing invasive mechanical ventilation enrolled in the TEAM study; 49 ICUs in 6 countries
- Participants
- 733 patients
- Comparison
- Early active mobilization vs usual care mobilization
Methodological detailsprospective, within-trial cost-effectiveness analysis, healthcare sector perspective, multicentre, 49 ICUs in 6 countries (Australia, New Zealand, UK, Ireland, Germany, Brazil)
- Prospective
- Within-trial cost-effectiveness analysis
- Healthcare sector perspective
- Multicentre
- 49 ICUs in 6 countries (Australia, New Zealand, UK, Ireland, Germany, Brazil)
Primary result
Incremental costs
Incremental costs
$1,823
95% CI -$10,552 to $12,027
As reported in the abstract
- Probability of early active mobilization being cost-effective, even at a willingness-to-pay threshold of $200,000/QALY
- less than 50%
Further findings
| Outcome | Incremental costs ($) (95% CI) | P value |
|---|---|---|
| Incremental costs (healthcare sector)Not significantly different | 1,823 (-$10,552 to $12,027) | |
| EuroQoL-5D 5-level utility scores · 6 monthsNot significantly different | P = 0.585 |
Incremental costs (healthcare sector)
- Significantly more staff hours delivering early active mobilization vs usual care mobilization
Probability of early active mobilization being cost-effective
- Less than 50%, even at willingness-to-pay threshold of $200,000/QALY
Sensitivity analyses incorporating meta-analysis data
- Early active mobilization may be cost-saving, but with lower QALY gains vs usual care mobilization
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →