Respiratory failure & ventilation
Cost-Effectiveness of In-Bed Cycling and Routine Physiotherapy for Patients Receiving Mechanical Ventilation
Authors' conclusion
In this trial-based economic evaluation, the differences in costs and QALYs between adding early in-bed cycling to usual physiotherapy and usual physiotherapy alone for adults receiving mechanical ventilation were not significantly different from 0.
Study context
- Population
- Adult intensive care unit (ICU) patients (≥18 years) receiving mechanical ventilation, 16 ICUs in Canada, the US and Australia
- Participants
- 360 patients · 16 ICUs
- Comparison
- Cycling plus usual physiotherapy vs Usual physiotherapy alone
- Primary endpoint
- Differences in costs (2024 CA$) and QALYs; incremental cost per QALY gained in the absence of dominance
- Follow-up
- 90 days
Methodological detailstrial-based, 90-day time horizon, societal perspective, multicentre, Enrollment November 1, 2016, to May 30, 2023; last follow-up August 3, 2023
- Trial-based
- 90-day time horizon
- Societal perspective
- Multicentre
- Enrollment November 1, 2016, to May 30, 2023; last follow-up August 3, 2023
Primary result
As reported in the abstract
Per-patient differences in 90-day costs and QALYs
Difference in costs
5841 CA$
95% CI -CA$7666 to CA$18 797
Cycling vs Usual care
Difference in quality-adjusted life-years (QALYs)
−0.0009 QALYs
95% CI −0.0185 to 0.0182
Cycling vs Usual care
- Probability of cycling plus usual physiotherapy being cost-effective at willingness-to-pay threshold of $50 000 per QALY gained
- 0.19
Further findings
Per-patient cost of providing early in-bed cycling
- Per-patient cost of cycling (CA$)
- 321
- Share of index hospitalization costs (CA$66 554)
- 0.5%
Original publication
Cost-Effectiveness of In-Bed Cycling and Routine Physiotherapy for Patients Receiving Mechanical Ventilation. JAMA Netw Open. Published 2 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →