Respiratory failure & ventilation
Cost-Effectiveness of Pantoprazole to Prevent Upper Gastrointestinal Bleeding in Mechanically Ventilated Patients
Authors' conclusion
In this economic evaluation, daily pantoprazole for invasively mechanically ventilated patients was less costly and more effective than care without pantoprazole, indicating both clinical benefits and economic value for the health care system.
Study context
- Population
- Critically ill adults receiving invasive ventilation, Canada, Australia, US, England, Saudi Arabia, Brazil, Kuwait and Pakistan
- Participants
- 4,821 adults · 68 intensive care unit (ICUs)
- Comparison
- Daily IV pantoprazole 40 mg vs placebo
- Primary endpoint
- Incremental cost per clinically important upper gastrointestinal bleed prevented (2025 US dollars)
- Follow-up
- ICU admission to hospital discharge or death
Methodological detailscost-effectiveness analysis, public health care payer's perspective, nonparametric bootstrapping, international multicentre
- Cost-effectiveness analysis
- Public health care payer's perspective
- Nonparametric bootstrapping
- International multicentre
Primary result
As reported in the abstract
Total per-patient costs (2025 US dollars)
- Pantoprazole more effective and less costly than no pantoprazole
- 99% of simulations
Further findings
ICU stay
Additional hospital stay
| Outcome | Pantoprazole | No pantoprazole | Incremental cost (95% CI) |
|---|---|---|---|
| Total per-patient costs, US costs (sensitivity analysis) | mean $130 179 (SD $123 456) | mean $140 770 (SD $153 195) | -$10 591 (-$18 448 to $−2735) |
Incremental costs excluding top 10% of patients (sensitivity analysis)
- Excluding top 10% by ICU days
- -$1151
- Excluding top 10% by ward days
- -$3388
- Excluding top 10% by total costs
- -$1356
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Cost-Effectiveness of Pantoprazole to Prevent Upper Gastrointestinal Bleeding in Mechanically Ventilated Patients. JAMA Netw Open. Published 1 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →