Effectiveness of prophylactic push-dose vasopressors for preventing arterial hypotension during elective orotracheal intubation: A systematic review and meta-analysis
Authors' conclusion
Prophylactic push-dose vasopressors modestly increase arterial pressure during tracheal intubation in elective surgical patients.
Study context
- Population
- Adult normotensive patients undergoing tracheal intubation, mostly ASA I–II elective procedures in operating rooms
- Participants
- 1,915 patients · 24 randomized controlled trials (RCTs)
- Comparison
- Prophylactic push-dose vasopressors vs no PDP during intubation
- Outcome
- Difference in mean arterial pressure (MAP) and systolic blood pressure (SBP) before and after intubation
Methodological detailsinverse variance method
- Inverse variance method
Pooled result
As reported in the abstract
MAP and SBP
PDP vs ControlsMean difference, mmHg (95 % CI)
MAP; I2 = 82 %
7.6(4.3–10.8)
SBP; I2 = 92 %
12.5(6.4–18.5)
Further pooled results
Sensitivity analyses (excluding phenylephrine; stratifying ephedrine doses)
- Consistent findings
Original publication
Effectiveness of prophylactic push-dose vasopressors for preventing arterial hypotension during elective orotracheal intubation: A systematic review and meta-analysis. J Crit Care. Published 30 September 2025. doi:10.
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