Respiratory failure & ventilation
Effects of different positive end-expiratory pressure titration strategies on mechanical power during ultraprotective ventilation in acute respiratory distress syndrome (ARDS) patients treated with veno-venous extracorporeal membrane oxygenation: A prospective interventional study
Authors' conclusion
An empirical PEEP of 10 cmH2O minimized MP, provided favorable hemodynamics, and increased oxygen delivery in ARDS patients treated with VV ECMO.
Study context
- Population
- ARDS patients on VV ECMO receiving ultraprotective ventilation
- Participants
- 20 patients
- Exposure
- PEEPELSO vs PEEPCstat,RS vs PEEPPtpexp
- Outcome
- Mechanical power (MP)
Methodological detailscrossover of three positive end-expiratory pressure (PEEP) titration strategies
- Crossover of three PEEP titration strategies
Main finding
As reported in the abstract
Mechanical power
PEEPELSO vs PEEPCstat,RS: P < 0.001 · PEEPELSO vs PEEPPtpexp: P < 0.001
Observational data: associations, not effects.
Further findings
PEEP level — PEEPELSO vs PEEPCstat,RS
P < 0.001
| Outcome | P value |
|---|---|
| PEEP levelPEEPELSO vs PEEPPtpexp | P < 0.001 |
| Lung stressPEEPELSO vs PEEPCstat,RS · less lung stress with PEEPELSO | P = 0.011 |
| Lung stressPEEPELSO vs PEEPPtpexp · less lung stress with PEEPELSO | P < 0.001 |
CO and oxygen delivery
- PEEPELSO increased CO and oxygen delivery
- P < 0.001 each
Original publication
Effects of different positive end-expiratory pressure titration strategies on mechanical power during ultraprotective ventilation in ARDS patients treated with veno-venous extracorporeal membrane oxygenation: A prospective interventional study. J Crit Care. Published 8 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →