Effects of different preoxygenation strategies on dynamic thiol-disulfide homeostasis and blood gas parameters in patients undergoing laparoscopic cholecystectomy
Authors' conclusion
Standard preoxygenation was found to induce greater oxidative stress and metabolic disturbances compared to rapid preoxygenation.
Study context
- Population
- ASA I–II patients scheduled for elective laparoscopic cholecystectomy
- Participants
- 62 patients
- Exposure
- Standard vs rapid preoxygenation with 100% O₂
- Outcome
- Thiol-disulfide homeostasis and blood gas parameters
- Follow-up
- Before preoxygenation (T0), after preoxygenation (T1), post-intubation (T2), surgery end (T3)
Main finding
As reported in the abstract
Thiol-disulfide homeostasis
- Group 1: significant decline in total thiol levels and trend toward increased disulfide levels
- Group 2: more stable thiol-disulfide dynamics
Observational data: associations, not effects.
Further findings
Blood gas parameters
- Greater acidosis, elevated lactate and increased pCO₂ in Group 1; more favorable acid-base and metabolic profiles in Group 2
- Despite longer surgical durations and higher smoking rates in Group 2
Original publication
Effects of different preoxygenation strategies on dynamic thiol-disulfide homeostasis and blood gas parameters in patients undergoing laparoscopic cholecystectomy. Perioper Med (Lond). Published 14 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →