ICU sedation, delirium & recovery
Effects of intraoperative sodium oxybate infusion on post-operative sleep quality in patients undergoing gynecological laparoscopic surgery: A randomized clinical trial
Primary result · Total RCSQ scoreResult — go to the resultMean difference 9 95% CI 2–16Authors' conclusion
Intraoperative sodium oxybate infusion improved post-operative sleep in patients who underwent gynecological laparoscopic surgery.
Study context
- Population
- Adults undergoing elective gynecological laparoscopic surgery, Shengjing Hospital of China Medical University, China178 analysed
- Participants
- 180 adults
- Comparison
- Sodium oxybate vs Saline
- Sodium oxybaten = 90
- Salinen = 90reference
- Primary endpoint
- Sleep quality (Richards-Campbell Sleep Questionnaire, Richards-Campbell Sleep Questionnaire (RCSQ))
- Follow-up
- POD one and three
Methodological detailssingle-center, prospective, two-arm, double-blinded
- Single-center
- Prospective
- Two-arm
- Double-blinded
Primary result
Total RCSQ score · over PODs one and three
Mean difference
9
95% CI 2–16
P = 0.010
Sodium oxybate vs Saline
mean difference 9 (95% CI 2–16); P = 0.010
As reported in the abstract
Secondary outcomes
Post-operative pain (VAS) · post-operative days (PODs) one and three
- No difference between the two groups
Post-operative sleep quality (Pittsburgh Sleep Quality Index) · one and three months post-operatively
- No difference between the two groups
Factors associated with post-operative sleep quality
- Age, surgery type, start time of surgery, and use of sufentanil-based patient-controlled intravenous analgesia significantly associated with post-operative sleep quality
Original publication
Effects of intraoperative sodium oxybate infusion on post-operative sleep quality in patients undergoing gynecological laparoscopic surgery: A randomized clinical trial. J Clin Anesth. Published 1 December 2023. doi:10.
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