Cardiothoracic & vascular anesthesia
Analgesic Effect and Sleep Quality of Low-Dose Dexmedetomidine in Cardiac Surgical Patients After Ultrafast-Track Extubation: A Randomized Clinical Trial
Authors' conclusion
Sedation with low-dose dexmedetomidine infusion for ultra-fast track extubation following cardiac surgery enhances sleep duration and quality.
Study context
- Population
- Patients aged 25 to 65 scheduled for elective cardiac surgery under GA with CPB, extubated immediately in the operating room
- Participants
- 22 vs 23
- Comparison
- Dex vs Placebo
- Dexn = 22
- Placebon = 23reference
Methodological detailsdouble-blind, single-centre
- Double-blind
- Single-centre
Primary result
As reported in the abstract
Total morphine consumption (mg) · 12 and 24 hours
- Dex vs Placebo: P = 0.707
- Dex vs Placebo: P = 0.502
Further findings
Total sleep time (BIS value ≤85) · significantly longer with Dex
P = 0.007
| Outcome | Dex | Placebo | P value |
|---|---|---|---|
| Sleep quality (Richard-Campbell Sleep Questionnaire)Better with Dex | 7.9 (interval 6.7–8.7) | 6.6 (interval 5.2–8.0) | P = 0.038 |
Original publication
Analgesic Effect and Sleep Quality of Low-Dose Dexmedetomidine in Cardiac Surgical Patients After Ultrafast-Track Extubation: A Randomized Clinical Trial. J Cardiothorac Vasc Anesth. Published 18 June 2024. doi:10.
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