Cardiothoracic & vascular anaesthesia
Evaluation of clinical impact of ultra fast-track versus conventional extubation in patients undergoing nonemergency cardiac surgery: ‘CARDU-FAST’': A randomised clinical trial
Authors' conclusion
Although UFT did not significantly reduce the primary composite outcome in the intention-to-treat (ITT) analysis, it was not associated with an increased risk of adverse events but was associated with improvements in several secondary outcomes.
Study context
- Population
- Adults undergoing major nonemergency cardiac surgery, tertiary cardiovascular centre
- Participants
- 612 adults
- Comparison
- Ultra Fast-Track vs Fast-Track
- UFTn = 306
- FTn = 306reference
- Primary endpoint
- Composite of:
- All-cause mortality
- Respiratory complications (prolonged intubation >24 h, reintubation, pneumonia)
- Stage III AKI (AKIN III)
Methodological detailssingle-centre, Conducted February 2023 to November 2024
- Single-centre
- Conducted February 2023 to November 2024
Primary result
As reported in the abstract
P = 0.105
Secondary outcomes
Prolonged intubation
P = 0.001
Need for NIV
P = 0.013
Intensive care unit (ICU) and hospital LOS; postoperative low cardiac output syndrome
- Shorter ICU and hospital LOS and lower incidence of low cardiac output syndrome with UFT vs FT
Safety
Reoperation for bleeding
P = 0.013
Original publication
Evaluation of clinical impact of ultra fast-track versus conventional extubation in patients undergoing nonemergency cardiac surgery: ‘CARDU-FAST’': A randomised clinical trial. Eur J Anaesthesiol. Published 28 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →