Effects of correction rate for severe hyponatremia in the intensive care unit on patient outcomes
Main findingResult — go to the resultAbsolute difference −4.37 % 95% CI −8.47 to −0.26%Authors' conclusion
Rapid correction (>8 mEq/L/day) of severe hyponatremia within the first 24 h was associated with lower in-hospital mortality and longer ICU and hospital-free days without an increase in neurological complication.
Study context
- Population
- ICU patients with sodium ≤120 mEq/L during ICU admission
- Participants
- 1,024 patients
- Exposure
- Rapid vs slow correction of severe hyponatremia over the first 24 h
- Rapidn = 451
- Slown = 573reference
- Outcome
- In-hospital mortality
Methodological detailsmulticentre ICU database, inverse probability weighting
- Multicentre ICU database
- Inverse probability weighting
Main finding
As reported in the abstract
Absolute difference
−4.37 %
95% CI −8.47 to −0.26%
Rapid vs Slow
absolute difference −4.37 % (95% CI −8.47 to −0.26%)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Days |
|---|---|
| Hospital-free days | 1.80 (95% CI 0.82 to 2.79 days) |
| ICU-free days | 1.16 (95% CI 0.15 to 2.17 days) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effects of correction rate for severe hyponatremia in the intensive care unit on patient outcomes. J Crit Care. Published 13 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →