Neuroanesthesia & neurocritical care
Effects of Fospropofol on intraoperative hemodynamics in patients undergoing Supratentorial tumor resection: A randomized controlled trial
Authors' conclusion
Fospropofol provided more stable intraoperative hemodynamics than propofol in patients undergoing supratentorial tumor resection without increasing the delirium risk.
Study context
- Population
- Patients scheduled for elective supratentorial tumor resectionincluded in analysis
- Participants
- 217 patients
- Comparison
- Fospropofol vs propofol for anaesthesia induction and maintenance
- Fospropofoln = 108
- Propofoln = 109reference
- Primary endpoint
- Area under the threshold (AUT) for MAP < 65 mmHg
Methodological detailsmulticentre, Fospropofol group had more males and a higher smoking rate
- Multicentre
- Fospropofol group had more males and a higher smoking rate
Primary result
As reported in the abstract
P < 0.05
Secondary outcomes
Intraoperative hypotension
P < 0.05
Time to recovery
P = 0.002
| Outcome | P value |
|---|---|
| Ephedrine useLess ephedrine required with fospropofol | P < 0.05 |
Safety
Delayed recovery
P = 0.005
Emergence and postoperative delirium
- Comparable between the two groups
- P > 0.05
Original publication
Effects of Fospropofol on intraoperative hemodynamics in patients undergoing Supratentorial tumor resection: A randomized controlled trial. J Clin Anesth. Published 23 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →