Neuroanesthesia & neurocritical care
The effect of hyperventilation versus normoventilation on cerebral oxygenation using near infrared spectroscopy in children undergoing posterior fossa tumor resection: A randomized controlled cross-over trial
Authors' conclusion
In children undergoing posterior fossa craniotomy, moderate hyperventilation reduced cerebral oxygenation without significant improvement of the surgical brain relaxation or the ICP.
Study context
- Population
- Children undergoing posterior fossa tumor resection under GAper protocol analysis
- Participants
- 42 children
- Comparison
- Mild hyperventilation vs normoventilation
- Early hyperventilationn = 23
- Early normoventilationn = 19reference
- Primary endpoint
- Cerebral oxygenation measured by near-infrared spectroscopy (NIRS)
Methodological detailsdouble-blinded, cross-over
- Double-blinded
- Cross-over
Primary result
As reported in the abstract
Cerebral oxygen saturation, hyperventilation vs normoventilation readings
Mean difference
13.45 ± 1.14 %
95% CI 11.14–15.76P < 0.0001
left side
Mean difference
11.47 ± 0.96 %
95% CI 11.14–15.76P < 0.0001
right side
Further findings
| Outcome | Early hyperventilation | Early normoventilation | Mean difference (95% CI) | P value | |
|---|---|---|---|---|---|
| ICP · end of phase 1 | mean 22.12 (SD 3.75) mmHg | mean 23.26 (SD 4.33) | −0.78 (−3.05 to 1.5) | P = 0.49 | |
| −4−202Difference (linear scale) |
Brain relaxation score · end of phase 1
- Similar in the two groups
Original publication
The effect of hyperventilation versus normoventilation on cerebral oxygenation using near infrared spectroscopy in children undergoing posterior fossa tumor resection: A randomized controlled cross-over trial. Anaesth Crit Care Pain Med. Published 21 December 2022. doi:10.
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