ICU sedation, delirium & recovery
Effects of melatonin on postoperative sleep quality: a systematic review, meta-analysis, and trial sequential analysis
Pooled resultResult — go to the resultMean difference −0.75 mm 95% CI −4.86 to 3.35Authors' conclusion
Our results indicate that melatonin supplementation does not improve postoperative sleep quality measured with the VAS compared with placebo in adult patients (GRADE: moderate).
Study context
- Population
- Adults undergoing surgery under GA or RA with sedation
- Participants
- 516 adults · 8 studies
- Comparison
- Melatonin or melatonin agonists vs placebo or no treatment
- Outcome
- Sleep quality measured using a visual analog scale (VAS)
Methodological detailstrial sequential analysis, random-effects model
- Trial sequential analysis
- Random-effects model
Pooled result
As reported in the abstract
Mean difference
−0.75 mm
95% CI −4.86 to 3.35
Melatonin vs Placebo
mean difference −0.75 mm (95% CI −4.86 to 3.35)
Safety
Postoperative adverse events
- Comparable between melatonin and control groups
Original publication
Effects of melatonin on postoperative sleep quality: a systematic review, meta-analysis, and trial sequential analysis. Can J Anaesth. Published 28 March 2023. doi:10.
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