ICU sedation, delirium & recovery
Effectiveness of sleep interventions to reduce delirium in critically ill patients: A systematic review and meta-analysis
Pooled result · Incidence of ICU deliriumResult — go to the resultRelative risk 0.73 95% CI 0.58–0.93Authors' conclusion
The current evidence suggests that non-pharmacological sleep interventions are not effective in preventing delirium in ICU patients.
Study context
- Population
- Critically ill ICU patients15 RCTs
- Comparison
- Sleep interventions vs control
- Outcome
- Incidence of ICU delirium
Methodological detailstrial sequential analysis
- Trial sequential analysis
Pooled result
As reported in the abstract
Relative risk
0.73
95% CI 0.58–0.93
P < 0.001
Sleep intervention vs Control
RR 0.73 (95% CI 0.58–0.93); P < 0.001
Further pooled results
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| ICU delirium incidence, dexmedetomidine trials (3 trials)Dexmedetomidine vs Control · pooled data from the three dexmedetomidine trials | 0.43 (0.32–0.59) | P < 0.001 | |
| 0.20.5125Relative risk (log scale) |
ICU delirium incidence and duration, other sleep interventions (light therapy, earplugs, melatonin, multicomponent nonpharmacologic)
- No significant effect on reducing incidence and duration of ICU delirium
- P > 0.05
Delirium occurrence (trial sequential analysis)
- Trial sequential analysis further confirms sleep interventions effective in reducing delirium occurrence
Original publication
Effectiveness of sleep interventions to reduce delirium in critically ill patients: A systematic review and meta-analysis. J Crit Care. Published 9 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →