ICU sedation, delirium & recovery
Effects of a multicomponent sleep enhancement protocol on delirium incidence in elderly critically ill surgical patients: a randomized controlled trial
Primary result · Delirium incidenceResult — go to the resultBayesian OR 0.55 95% CrI 0.22–1.31Authors' conclusion
Among elderly surgical ICU patients, a multicomponent, non-pharmacologic sleep enhancement protocol was associated with a high posterior probability of reducing delirium during the early ICU period, despite no measurable improvement in subjective sleep quality.
Study context
- Population
- Patients aged ≥ 65 years in a surgical ICU with expected ICU stays > 24 hanalysed
- Participants
- 177 patients
- Comparison
- Multicomponent sleep enhancement protocol vs usual care
- Interventionn = 89
- Controln = 88reference
- Primary endpoint
- Delirium incidence (Thai version of CAM-ICU, blinded evaluators)
- Follow-up
- 7 days
Methodological detailsprospective, single-blind, Bayesian analysis
- Prospective
- Single-blind
- Bayesian analysis
Primary result
Delirium incidence
Bayesian OR
0.55
95% CrI 0.22–1.31
By group
Intervention vs Control
Bayesian OR 0.55 (95% CrI 0.22–1.31)
As reported in the abstract
Further findings
Delirium incidence, predefined high-risk subgroup (subgroup) · 7 days
- Delirium incidence, intervention vs control
- 14.0% vs. 30.0%
- OR
- 0.38
- 95% CrI
- 0.12-1.83
- Posterior probability of benefit
- 95.7%
- Bayesian analysis; CrI
Sleep quality (Richards-Campbell Sleep Questionnaire (RCSQ)) and clinical outcomes
- Did not differ significantly
Original publication
Effects of a multicomponent sleep enhancement protocol on delirium incidence in elderly critically ill surgical patients: a randomized controlled trial. J Intensive Care. Published 3 November 2025. doi:10.
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