ICU sedation, delirium & recovery
Remote Multicomponent Rehabilitation and Cost-Effectiveness in Survivors of Critical Illness
Authors' conclusion
In this economic analysis, among ICU survivors overall, a remotely delivered multicomponent rehabilitation program was not cost-effective from a UK NHS-PSS perspective.
Study context
- Population
- Adults within 12 weeks of hospital discharge after intensive care unit (ICU) admission for critical illness with mechanical ventilation ≥48 h, 52 National Health Service (NHS) hospitals, UK
- Participants
- 429 adults
- Comparison
- Rehabilitation vs Standard care
- Rehabilitationn = 231
- Standard caren = 198reference
- Primary endpoint
- Incremental cost per QALY gained (costs in 2024 UK pounds sterling; Quality-adjusted life-years (QALYs) from trial data)
- Follow-up
- 6 months
Methodological detailspragmatic, multicentre, assessor-blinded, 6-month time horizon, NHS-PSS and societal perspectives, December 2022 to November 2025
- Pragmatic
- Multicentre
- Assessor-blinded
- 6-month time horizon
- NHS-PSS and societal perspectives
- December 2022 to November 2025
Primary result
As reported in the abstract
Incremental cost per QALY gained (NHS-PSS perspective, 6-month horizon)
Mean cost difference
1250 £ per participant
95% CI £562-£1938
Rehabilitation
QALY difference
0.023 QALYs per participant (95% CI 0.007–0.040)
Rehabilitation
- Incremental cost-effectiveness ratio (ICER), £ per QALY
- £54 034 per QALY
- Probability of being cost-effective at £20 000 per QALY threshold
- 3%
- Probability of being cost-effective at £30 000 per QALY threshold
- 11%
Further findings
ICER, patients with mechanical ventilation for 7 days or less (subgroup)
- Intervention cost-effective; ICER, £ per QALY
- £21 476 per QALY
ICER, societal perspective
- Intervention cost-effective; ICER, £ per QALY
- £6341 per QALY
Original publication
Remote Multicomponent Rehabilitation and Cost-Effectiveness in Survivors of Critical Illness. JAMA Netw Open. Published 3 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →