ICU sedation, delirium & recovery
Precision Exercise Effect on Fatigue and Function in Lung Cancer Surgery: A Randomized Clinical Trial
Authors' conclusion
The PEP intervention, a personalized, clinic-aligned, and remotely monitored perioperative exercise program for patients with lung cancer undergoing surgery demonstrated improvements in physical function for women and significant improvements in fatigue scores across all groups.
Study context
- Population
- Adults undergoing surgery for primary lung cancer (stages I-IIIa) or oligometastatic disease to the lungITT population
- Participants
- 182 adults
- Comparison
- Exercise vs Standard care
- Exercisen = 92
- Standard caren = 90reference
- Primary endpoint
- Physical function (6MWT), Short Physical Performance Battery and cancer-related fatigue (FACIT-Fatigue)
- Follow-up
- 2 months after surgery
Methodological detailssingle-centre, phase 3, Enrolled November 2017 to 2021, continued during the COVID-19 pandemic
- Single-centre
- Phase 3
- Enrolled November 2017 to 2021, continued during the COVID-19 pandemic
Primary result
As reported in the abstract
6MWT distance
| Group | Value | Baseline mean (SE), m |
|---|---|---|
| Exercise | mean 482.2 (SE 14.1) m | 467.9 (13.0) |
| Standard care | mean 471.5 (SE 14.0) m | 481.4 (11.1) |
Value
Exercisemean 482.2 (SE 14.1) m
Standard caremean 471.5 (SE 14.0) m
Baseline mean (SE), m
Exercise467.9 (13.0)
Standard care481.4 (11.1)
Further findings
6MWT distance, women (subgroup) · 2 months after surgery
- Greater between-group effect among women: mean (SE) 37.8 (17.3) m, P = .03
Short Physical Performance Battery, women (subgroup) · 2 months after surgery
- Greater improvement among women: mean (SE) 0.9 (0.4), P = .04
Cancer-related fatigue (FACIT-Fatigue) · 2 months after surgery
- Stable fatigue scores in the exercise group; deterioration in the standard-care group: mean (SD) 3.7 (1.4), P = .009
- Greater effect sizes among younger, rural, overweight or obese, and primary lung cancer participants
Original publication
Precision Exercise Effect on Fatigue and Function in Lung Cancer Surgery: A Randomized Clinical Trial. JAMA Surg. Published 1 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →