ICU sedation, delirium & recovery
Effects of Specialist Palliative Care for Patients Undergoing Major Abdominal Surgery for Cancer: A Randomized Clinical Trial
Primary resultResult — go to the resultOdds ratio 1.17 95% CI 0.77–1.80Authors' conclusion
This randomized clinical trial showed no evidence that early specialist palliative care improves the QoL of patients undergoing nonpalliative cancer operations.
Study context
- Population
- Patients scheduled for specified intra-abdominal cancer operations for cure or durable control of cancer, academic urban referral centre, Southeastern USrandomised 1:1
- Participants
- 235 patients
- Comparison
- Specialist palliative care vs usual care
- Primary endpoint
- Physical and functional QoL (FACT-G Trial Outcome Index (TOI), range 0–56, higher = better)
- Follow-up
- POD 90
Methodological detailssingle-centre, Specialist palliative care received by 114 (97%) in the intervention group and 1 (1%) in the usual care group
- Single-centre
- Specialist palliative care received by 114 (97%) in the intervention group and 1 (1%) in the usual care group
Primary result
As reported in the abstract
Odds ratio
1.17
95% CI 0.77–1.80
P = 0.46
By group
Intervention
46.77
adjusted median · 95% CI 44.18–49.04
Usual care
46.23
adjusted median · 95% CI 43.08–48.14
Intervention vs Usual care
OR 1.17 (95% CI 0.77–1.80); P = 0.46
Secondary outcomes
| Outcome | Estimate | |
|---|---|---|
| Overall QoL (FACT-G) · POD 90Intention-to-treat | OR 1.09 (95% CI 0.75–1.58) | |
| Days alive at home · POD 90Intention-to-treat | OR 0.87 (95% CI 0.69–1.11) | |
| Overall survival · 1 yearIntention-to-treat | HR 0.97 (95% CI 0.50–1.88), event not clearly stated | |
| 0.512Ratio (log scale) |
Overall quality of life (QoL) (Functional Assessment of Cancer Therapy-General (FACT-G)) · postoperative day (POD) 90
- Palliative care did not improve overall QoL
Days alive at home · POD 90
- Palliative care did not improve days alive at home
Overall survival · 1 year
- Palliative care did not improve 1-year overall survival
Original publication
Effects of Specialist Palliative Care for Patients Undergoing Major Abdominal Surgery for Cancer: A Randomized Clinical Trial. JAMA Surg. Published 1 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →