ICU sedation, delirium & recovery
Effects of the ABCDEF Bundle on Delirium, Function, and Quality of Life in Australian ICU Patients: A Pragmatic Randomized Controlled Trial
Primary resultResult — go to the resultOdds ratio 1.1 95% CI 0.5–2.2Authors' conclusion
In adult ICU patients, the ABCDEF bundle, compared with usual care, did not reduce the cumulative incidence or duration of delirium.
Study context
- Population
- Critically ill adults expected to remain in ICU for at least 48 hours, single metropolitan Australian medical/surgical ICU
- Comparison
- ABCDEF bundle vs usual care
- Primary endpoint
- Cumulative incidence of delirium (Confusion Assessment Method for ICU)
Methodological detailssingle-centre, pragmatic, Complete ABCDEF bundle adherence in 50% of patients each study day
- Single-centre
- Pragmatic
- Complete ABCDEF bundle adherence in 50% of patients each study day
Primary result
As reported in the abstract
Odds ratio
1.1
95% CI 0.5–2.2
P = 0.86
By group
ABCDEF vs Usual care
OR 1.1 (95% CI 0.5–2.2); P = 0.86
Further findings
| Outcome | ABCDEF | Usual care | Mean difference (d) (95% CI) | P value | |
|---|---|---|---|---|---|
| Delirium duration | median 2.0 (IQR 1.3–3.5) d | median 2.5 (IQR 1.0–4.4) d | −0.4 (−1.6 to 0.8) | P = 0.53 | |
| −2−101Difference, d (linear scale) |
Median
| Outcome | ABCDEF | Usual care | Mean difference (95% CI) | P value | |
|---|---|---|---|---|---|
| Functional score (Functional Independence Measure) · ICU discharge | 55.0 (IQR 37.0–67.3) | 53.0 (IQR 43.8–62.5) | 0.0 (−7.7 to 7.6) | P = 0.83 | |
| −10−50510Difference (linear scale) |
| Outcome | P value |
|---|---|
| Quality of life (EuroQol 5D five-level) · 90 days post-ICU dischargeHigher "usual activities" domain scores with ABCDEF | P < 0.001 |
Quality of life (EuroQol 5D five-level) · 90 days post-ICU discharge
- No differences in other domains
Original publication
Effects of the ABCDEF Bundle on Delirium, Function, and Quality of Life in Australian ICU Patients: A Pragmatic Randomized Controlled Trial. Crit Care Med. Published 20 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →