Perioperative medicine & outcomes
Effects of a Pragmatic Home-based Exercise Program Concurrent With Neoadjuvant Therapy on Physical Function of Patients With Pancreatic Cancer: The PancFit Randomized Clinical Trial
Authors' conclusion
In this randomized trial of prescribed exercise versus enhanced usual care during neoadjuvant therapy for pancreatic cancer, a high volume of physical activity and increased exercise capacity were observed in both arms
Study context
- Population
- Patients with pancreatic cancer receiving neoadjuvant therapy; all received nutrition counseling and activity trackersrandomised
- Participants
- 151 patients
- Comparison
- Arm A vs Arm B
- Primary endpoint
- 6-minute walk distance (6MWD; ≥14 m improvement clinically meaningful)
Primary result
As reported in the abstract
Change in 6MWD
| Group | Value | P (within-group) |
|---|---|---|
| Arm A | mean 18.6 (SD 56.8) m | P =0.01 |
| Arm B | mean 27.3 (SD 68.1) m | P =0.002 |
Value
Arm Amean 18.6 (SD 56.8) m
Arm Bmean 27.3 (SD 68.1) m
P (within-group)
Arm AP =0.01
Arm BP =0.002
Secondary outcomes
Objectively measured weekly activity · similar
P = 0.62
Self-reported weekly moderate-to-strenuous physical activity · similar
P = 0.49
Increase in weekly strength training sessions · increased more in Arm B
P < 0.001
Quality of life and clinical outcomes
- Did not significantly differ between arms
Exercise and physical activity, both arms pooled
- Favorably associated with physical performance and clinical outcomes
Original publication
Effects of a Pragmatic Home-based Exercise Program Concurrent With Neoadjuvant Therapy on Physical Function of Patients With Pancreatic Cancer: The PancFit Randomized Clinical Trial. Ann Surg. Published 7 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →