Effects of Preoxygenation With Intratracheal Suctioning During Extubation: An Alternating Cluster-Controlled Trial (INtratracheal suctioning and oxygenation AT Extubation [INNOVATE])
Main findingResult — go to the resultOdds ratio 0.77 95% CI 0.60–0.98Authors' conclusion
Extubation with a low-inspired oxygen fraction and without suctioning appears safe and may improve patient-relevant outcomes.
Study context
- Population
- Adult patients extubated in a tertiary level interdisciplinary ICU
- Participants
- 3,675 patients
- Comparison
- FiO2 35% without suctioning vs FiO2 100% with suctioning at extubation
- F io2 100% with suctioningn = 1,877reference
- F io2 35% without suctioningn = 1,798
- Outcome
- Composite of:
- Reintubation
- NIV
- Follow-up
- Within 48 hours after extubation
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Odds ratio
0.77
95% CI 0.60–0.98
P = 0.032
F io2 35% without suctioning vs F io2 100% with suctioning
OR 0.77 (95% CI 0.60–0.98); P = 0.032
Secondary outcomes
| Outcome | Mean difference (kPa) (95% CI) | P value | |
|---|---|---|---|
| PaO2/FiO2 ratio after extubation | 4.72 (4.12–5.32) | P < 0.001 | |
| −50510Difference, kPa (linear scale) |
Original publication
Effects of Preoxygenation With Intratracheal Suctioning During Extubation: An Alternating Cluster-Controlled Trial (INtratracheal suctioning and oxygenation AT Extubation [INNOVATE]). Crit Care Med. Published 7 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →