Nociception index–monitored extubation is associated with improved hemodynamic stability and recovery efficiency in the post-anesthesia care unit: a single-center randomized controlled trial
Authors' conclusion
NOX-monitored extubation improved hemodynamic stability and reduced PACU recovery time but was associated with paradoxical cardiorespiratory trade-offs.
Study context
- Population
- Patients undergoing surgery with postoperative intubation, extubated in the post-anesthesia care unit (PACU)
- Participants
- 120 patients
- Comparison
- NOX-monitored extubation vs standard monitoring in the PACU
- NOXn = 60
- Standard monitoringn = 60reference
- Primary endpoint
- Hemodynamic stability and recovery efficiency in the PACU
Methodological detailssingle-centre, Baseline hypertension more prevalent in NOX group (21.7% vs. 0%)
- Single-centre
- Baseline hypertension more prevalent in NOX group (21.7% vs. 0%)
Primary result
As reported in the abstract
- Attenuated BP response at awakening in NOX vs controls: SBP - 7.3%, DBP - 9.0% (both p < 0.05)
- PACU discharge faster in NOX (≈42% reduction)
Further findings
Median, min
| Outcome | NOX | Standard monitoring | P value |
|---|---|---|---|
| Time to PACU discharge≈42% reduction | 27.5 | 50.5 | P < 0.001 |
Safety
| Outcome | P value |
|---|---|
| Heart-rate increase | P = 0.008 |
| Oxygen desaturation | P < 0.001 |
| Complications | P = 0.306 |
Heart-rate increase
- Greater HR increase (+ 14.5 vs. + 7.4 bpm)
Oxygen desaturation
- Greater oxygen desaturation (−2.28% vs. - 0.70%)
Complications
- Complication rates similar (11.7% vs. 18.3%)
Original publication
Nociception index–monitored extubation is associated with improved hemodynamic stability and recovery efficiency in the post-anesthesia care unit: a single-center randomized controlled trial. J Clin Monit Comput. Published 2 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →