Association Between Intraoperative Alveolar Dead Space Fraction and Early Extubation After Glenn and Fontan Procedures
Authors' conclusion
AVDSF measured at CPB weaning and the end of the procedure was significantly lower in patients extubated within 24 hours, suggesting that intraoperative AVDSF is associated with early extubation after Glenn or Fontan procedures.
Study context
- Population
- Patients undergoing Glenn or Fontan procedures, single tertiary centre, 2019–2024Glenn 44, Fontan 48
- Participants
- 92 patients
- Exposure
- Early extubation vs prolonged ventilation
- En = 79
- Pn = 13reference
- Outcome
- Median AVDSF
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
| Group | Value | At cardiopulmonary bypass (CPB) weaning | At procedure end |
|---|---|---|---|
| E | median 0.13 | 0.18 | 0.12 |
| P | median 0.11 | 0.29 | 0.26 |
Value
Emedian 0.13
Pmedian 0.11
At cardiopulmonary bypass (CPB) weaning
E0.18
P0.29
At procedure end
E0.12
P0.26
- E vs P: P = 0.67 — at procedure start
- E vs P: P = 0.01 — at CPB weaning
- E vs P: P = 0.02 — at procedure end
- AUC for alveolar dead space fraction (AVDSF) at procedure end associated with early extubation
- 0.70
Observational data: associations, not effects.
Further findings
Ventilation duration
P < 0.001
ICU LOS
P < 0.001
Hospital LOS
P < 0.001
In-hospital mortality
P = 0.02
Safety
Cardiovascular reintervention
P < 0.001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association Between Intraoperative Alveolar Dead Space Fraction and Early Extubation After Glenn and Fontan Procedures. J Cardiothorac Vasc Anesth. Published 7 May 2026. doi:10.
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