Effects of Real-Time Automated Clinical Deterioration Alert and Trigger Systems on Clinical Outcomes in Adult General Ward Patients: A Systematic Review and Meta-Analysis
Pooled result · Hospital mortality and IHCA (co-primary)Result — go to the resultRelative risk 0.60 95% CI 0.43–0.85Authors' conclusion
Real-time clinical deterioration automated alert and trigger systems are associated with reduced in-hospital cardiac arrests and may offer mortality benefits when integrated into structured escalation pathways.
Study context
- Population
- Adult general ward patients
- Participants
- 349,818 patients · 18 studies
- Comparison
- Automated alert and trigger systems vs Conventional manual escalation
- Outcome
- Hospital mortality and in-hospital cardiac arrest
Methodological detailsrandom-effects meta-analysis, All studies had at least moderate risk of bias
- Random-effects meta-analysis
- All studies had at least moderate risk of bias
Pooled result
Hospital mortality and IHCA (co-primary)
Relative risk
0.60
95% CI 0.43–0.85
P = 0.004
Automated alert and trigger systems vs Conventional manual escalation
RR 0.60 (95% CI 0.43–0.85); P = 0.004
As reported in the abstract
Further pooled results
ICU LOS
- ICU LOS significantly reduced (one RCT and one before-and-after study)
Hospital LOS and unplanned ICU transfers
- No significant effects in alert-eligible or all-admission cohorts
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effects of Real-Time Automated Clinical Deterioration Alert and Trigger Systems on Clinical Outcomes in Adult General Ward Patients: A Systematic Review and Meta-Analysis. Crit Care Med. Published 12 November 2025. doi:10.
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