Effects of restrictive fluid therapy on the time to resolution of hyperlactatemia in intensive care unit (ICU) patients with septic shock. A secondary post hoc analysis of the CLASSIC randomized trial
Authors' conclusion
In this post hoc retrospective analysis of a multicenter randomized controlled trial (RCT), a restrictive intravenous fluid strategy did not seem to affect the time to resolution of hyperlactatemia in adult ICU patients with septic shock.
Study context
- Population
- Adult ICU patients with septic shock (sub-cohort of the CLASSIC trial with serial plasma lactate)CLASSIC sub-cohort
- Participants
- 777 patients
- Comparison
- Restrictive vs standard intravenous (IV) fluid therapy
- Restrictiven = 385
- Standardn = 392reference
Methodological detailspost hoc, multicentre, international, competing-risks regression
- Post hoc
- Multicentre
- International
- Competing-risks regression
Primary result
As reported in the abstract
Time to resolution of hyperlactatemia
Restrictive vs StandardHR for resolution of hyperlactatemia (CI)
Day 1; unadjusted, time split
0.94(0.78–1.14)
Day 2-3; unadjusted, time split
1.21(0.89–1.65)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effects of restrictive fluid therapy on the time to resolution of hyperlactatemia in ICU patients with septic shock. A secondary post hoc analysis of the CLASSIC randomized trial. Intensive Care Med. Published 10 April 2024. doi:10.
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