Efficacy and safety of neuraxial hydromorphone: A systematic review and meta-analysis with trial sequential analysis
Pooled resultResult — go to the resultMean difference −0.4 95 % CI −0.8 to −0.1Authors' conclusion
In conclusion, there is very low level of evidence that neuraxial hydromorphone provides effective analgesia after surgery or labor, at the expense of an increased rate of pruritus.
Study context
- Population
- Any patient undergoing any type of surgery or in labor
- Participants
- 436 participants · 6 trials
- Comparison
- Neuraxial hydromorphone vs control
- Outcome
- Rest pain score (analogue scale, 0-10) by route (epidural vs spinal) and type of surgery (orthopedic vs other)
- Follow-up
- Up to 24 h
Methodological detailstrial sequential analysis
- Trial sequential analysis
Pooled result
As reported in the abstract
Mean difference
−0.4
95 % CI −0.8 to −0.1
P = 0.01
Hydromorphone vs Control
mean difference −0.4 (95 % CI −0.8 to −0.1); P = 0.01
Safety
| Outcome | RR (95 % CI) | P value | |
|---|---|---|---|
| PONVI2 = 27 % | 1.2 (0.8–1.8) | P = 0.47 | |
| PruritusI2 = 0 % | 3.1 (1.6–5.9) | P = 0.0005 | |
| 0.20.5125Relative risk (log scale) |
Original publication
Efficacy and safety of neuraxial hydromorphone: A systematic review and meta-analysis with trial sequential analysis. J Clin Anesth. Published 22 October 2024. doi:10.
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