Glucocorticoids added to paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) for post‐operative pain: A systematic review with meta‐analysis and trial sequential analysis
Pooled result · Cumulative opioid consumptionResult — go to the resultMD −0.28 95% CI −1.90 to 1.33Authors' conclusion
Glucocorticoids added to a baseline therapy of paracetamol and an NSAID likely result in little to no difference in cumulative opioid consumption and pain at rest at 24 h postoperatively.
Study context
- Population
- Adults undergoing any type of surgery
- Participants
- 804 adults · 9 trials
- Comparison
- Glucocorticoids vs Placebo/no intervention
- Outcome
- Three primary outcomes: cumulative opioid consumption, serious adverse events and pain at rest
- Follow-up
- 24 h postoperatively
Methodological detailstrial sequential analysis, GRADE certainty assessment, Risk of Bias 2 tool, trial sequential analysis (TSA) showed insufficient information for most outcomes
- Trial sequential analysis
- GRADE certainty assessment
- Risk of Bias 2 tool
- TSA showed insufficient information for most outcomes
Pooled result
Cumulative opioid consumption
MD
−0.28
95% CI −1.90 to 1.33
P = 0.68
Glucocorticoids vs Placebo/no intervention
MD −0.28 (95% CI −1.90 to 1.33); P = 0.68
As reported in the abstract
Further pooled results
| Outcome | MD (95% CI) | P value | |
|---|---|---|---|
| Pain at rest (NRS) (primary outcome) · 24 h postoperativelyTSA-adjusted CI; moderate certainty of evidence · high risk of bias | −0.39 (−0.84 to 0.17) | P = 0.10 | |
| −1−0.500.5Difference (linear scale) |
Safety
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Serious adverse events (primary outcome)TSA-adjusted CI; very low certainty of evidence · high risk of bias | 0.99 (0.27–3.63) | P = 0.93 | |
| 0.20.5125Relative risk (log scale) |
Original publication
Glucocorticoids added to paracetamol and NSAIDs for post‐operative pain: A systematic review with meta‐analysis and trial sequential analysis. Acta Anaesthesiol Scand. Published 23 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →