Perioperative medicine & outcomes
Risks of serious adverse events with non‐steroidal anti‐inflammatory drugs in gastrointestinal surgery: A systematic review with meta‐analysis and trial sequential analysis
Pooled result · SAEsResult — go to the resultRelative risk 0.78 95% CI 0.51–1.19Authors' conclusion
In adult patients undergoing gastrointestinal surgery, there was insufficient information to draw firm conclusions on the effects of NSAIDs on SAEs. The certainty of the evidence was very low.
Study context
- Population
- Patients undergoing gastrointestinal surgery
- Participants
- 1,622 patients · 22 RCTs
- Comparison
- Non-steroidal anti-inflammatory drugs (NSAIDs) vs placebo, usual care or no intervention
- Outcome
- Incidence of serious adverse events (SAEs)
Methodological detailstrial sequential analysis, GRADE certainty assessment
- Trial sequential analysis
- GRADE certainty assessment
Pooled result
SAEs
Relative risk
0.78
95% CI 0.51–1.19
P = 0.24
NSAIDs vs Placebo
RR 0.78 (95% CI 0.51–1.19); P = 0.24
As reported in the abstract
Further pooled results
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| SAEs, post-hoc beta-binomial regression including trials with zero events (sensitivity analysis)Post-hoc | 0.73 (0.54–0.99) | P = 0.042 | |
| 0.512Odds ratio (log scale) |
Original publication
Risks of serious adverse events with non‐steroidal anti‐inflammatory drugs in gastrointestinal surgery: A systematic review with meta‐analysis and trial sequential analysis. Acta Anaesthesiol Scand. Published 17 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →