Perioperative medicine & outcomes
Nonsteroidal anti-inflammatory drug use and acute kidney injury in nephrectomies: A retrospective propensity score-matched cohort study
Main findingResult — go to the resultHazard ratio 0.98 95% CI 0.80–1.19Authors' conclusion
Perioperative use of NSAIDs in patients having nephrectomies was not associated with a greater risk of AKI, and possibly reduced the duration of hospitalization.
Study context
- Population
- Adults ≥18 years having partial or radical nephrectomy
- Participants
- 3,359 adults · 739 matched pairs
- Exposure
- Perioperative IV nonsteroidal anti-inflammatory drugs (NSAID) vs no NSAID
- Outcome
- Postoperative AKI (Kidney Disease: Improving Global Outcomes criteria)
Methodological detailspropensity-score matched
- Propensity-score matched
Main finding
As reported in the abstract
Hazard ratio
0.98
95% CI 0.80–1.19
P = 0.90
By group
NSAID vs No NSAID
HR 0.98 (95% CI 0.80–1.19); P = 0.90
Observational data: associations, not effects.
Secondary outcomes
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| AKI stageAKI stages not worse · propensity-score-matched | 0.99 (0.79–1.24) | P = 0.91 | |
| 0.512Odds ratio (log scale) |
| Outcome | P value |
|---|---|
| Duration of postoperative hospitalizationShorter postoperative hospitalization with NSAID · propensity-score-matched | P < 0.001 |
Safety
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| NSAID-related side effects | 1.50 (0.42–5.32) | P = 0.53 | |
| 0.20.5125Odds ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Nonsteroidal anti-inflammatory drug use and acute kidney injury in nephrectomies: A retrospective propensity score-matched cohort study. Anaesth Crit Care Pain Med. Published 26 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →