Perioperative medicine & outcomes
Anti-inflammatory and anti-nociceptive effects of individualized blood pressure strategy based on low-dose noradrenaline infusion in elderly patients following major surgery: A randomized, controlled study
Primary result · TNF-αResult — go to the resultDifference −4.58 pg/ml 95 % CI −7.56 to −1.58Authors' conclusion
Among elderly patients undergoing major surgery, an individualized mean arterial pressure strategy management based on low-dose norepinephrine reduced surgical stress responses and attenuated the release of proinflammatory cytokines TNF-α and IL-6. It was also associated with a lower risk of AKI.
Study context
- Population
- Patients older than 60 years, ASA II–III, scheduled for hepatobiliary and pancreatic surgery, China100 completed, mITT analysis
- Participants
- 108 participants
- Comparison
- Individualized mean arterial pressure (MAP) strategy vs standard
- Primary endpoint
- TNF-α
- Follow-up
- 24 h after surgery
Methodological detailsprospective, single-centre, First Affiliated Hospital of Anhui Medical University, China, December 2021 to July 2023
- Prospective
- Single-centre
- First Affiliated Hospital of Anhui Medical University, China, December 2021 to July 2023
Primary result
As reported in the abstract
24 h
Difference
−4.58 pg/ml
95 % CI −7.56 to −1.58
P = 0.003
By group
Individualized vs Standard
difference −4.58 pg/ml (95 % CI −7.56 to −1.58); P = 0.003
Secondary outcomes
%
| Outcome | Individualized | Standard | RR (95 % CI) | P value | |
|---|---|---|---|---|---|
| Postoperative AKI · within 7-day after surgery | 6 | 20 | 3.33 (0.95–11.39) | P = 0.037 | |
| 0.050.21520Relative risk (log scale) |
IL-6, cortisol and IL-10
- Relatively mild increase from baseline after surgery in IL-6 and cortisol, except for IL-10
Original publication
Anti-inflammatory and anti-nociceptive effects of individualized blood pressure strategy based on low-dose noradrenaline infusion in elderly patients following major surgery: A randomized, controlled study. J Clin Anesth. Published 23 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →