Perioperative medicine & outcomes
Mean arterial pressure versus cardiac index for haemodynamic management and myocardial injury after hepatopancreatic surgery: A randomised controlled trial
Authors' conclusion
CI-based haemodynamic management assures sufficient flow and consequently is associated with less peri-operative hsTnT elevation and lower incidence of MINS compared to MAP.
Study context
- Population
- Patients ≥ 65 years, or ≥ 45 years with at least one cardiac risk factor, undergoing hepatic/pancreatic surgery at a university-affiliated tertiary hospital, June 2022 to March 2023completed the study
- Participants
- 91 patients
- Comparison
- CI-based vs mean arterial pressure (MAP)-based haemodynamic management
- CIn = 46
- MAPn = 45reference
- Primary endpoint
- Peri-operative high-sensitive troponin-T (hsTnT) elevation
Methodological detailssingle-centre
- Single-centre
Primary result
Absolute troponin elevation
Median difference
5.1 ng l −1
95% CI 3–7
P < 0.001
By group
CI-based vs MAP-based
median difference 5.1 ng l −1 (95% CI 3–7); P < 0.001
As reported in the abstract
Secondary outcomes
| Outcome | CI | MAP | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| MINS incidence | 17.4% | 37.8% | 0.46 (0.22–0.96) | P = 0.029 | |
| 0.20.5125Relative risk (log scale) |
MAP-AUC
P = 0.85
CI-AUC
P < 0.001
| Outcome | χ2 | P value |
|---|---|---|
| All-cause mortality (90-day) | 1.98 | P = 0.16 |
All-cause mortality (90-day)
- Two MAP patients died from cardiovascular-related causes; one CI and two MAP patients died from sepsis-related complications
Original publication
Mean arterial pressure versus cardiac index for haemodynamic management and myocardial injury after hepatopancreatic surgery: A randomised controlled trial. Eur J Anaesthesiol. Published 12 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →