Risks of Serious Adverse Events Associated With Non‐Steroidal Anti‐Inflammatory Drugs in Orthopaedic Surgery. A Systematic Review With Meta‐Analysis and Trial Sequential Analysis
Pooled result · Serious adverse eventsResult — go to the resultRelative risk 0.83 95% CI 0.61–1.14Authors' conclusion
In adult patients undergoing orthopaedic surgery, we found no evidence of a difference between NSAID and placebo regarding risk of serious adverse events.
Study context
- Population
- Patients undergoing orthopaedic surgery
- Participants
- 6,593 patients · 38 trials
- Comparison
- Perioperative NSAID vs placebo, usual care, or no intervention
- Outcome
- Incidence of serious adverse events
Methodological detailstrial sequential analysis, GRADE certainty assessment
- Trial sequential analysis
- GRADE certainty assessment
Pooled result
Serious adverse events
Relative risk
0.83
95% CI 0.61–1.14
P = 0.26
NSAID vs Placebo
RR 0.83 (95% CI 0.61–1.14); P = 0.26
As reported in the abstract
Further pooled results
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Serious adverse events, incl. zero-event trials (post hoc beta-binomial regression sensitivity analysis)Post hoc | 0.89 (0.76–1.06) | P = 0.19 | |
| 0.512Odds ratio (log scale) |
Original publication
Risks of Serious Adverse Events Associated With Non‐Steroidal Anti‐Inflammatory Drugs in Orthopaedic Surgery. A Systematic Review With Meta‐Analysis and Trial Sequential Analysis. Acta Anaesthesiol Scand. Published 16 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →