Efficacy and safety of perioperative use of non-steroidal anti-inflammatory drugs for preemptive analgesia in lumbar spine surgery: a systematic review and meta-analysis
Authors' conclusion
Our findings suggest that NSAIDs are effective and safe for preemptive analgesia in the perioperative period of lumbar spine surgery
Study context
- Population
- Patients undergoing lumbar spine surgery
- Participants
- 845 patients · 12 randomized controlled trials (RCTs)
- Comparison
- Perioperative preemptive NSAID analgesia
- Outcome
- Efficacy (postoperative morphine consumption, VAS, NRS)
Methodological detailsSearched PubMed, ScienceDirect, Cochrane Library, Web of Science
- Searched PubMed, ScienceDirect, Cochrane Library, Web of Science
Pooled result
As reported in the abstract
- Postoperative morphine consumption
- P < 0.05
- VAS
- P < 0.05
- NRS
- P < 0.05
Safety
- Not statistically associated with postoperative complications
- P > 0.05
Original publication
Efficacy and safety of perioperative use of non-steroidal anti-inflammatory drugs for preemptive analgesia in lumbar spine surgery: a systematic review and meta-analysis. Perioper Med (Lond). Published 23 November 2023. doi:10.
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