Incidence of kidney toxicity of non-steroidal anti-inflammatory drugs in critically ill patients
Authors' conclusion
In critically ill patients, the use of NSAIDs is associated with AKI and may lead to a worse prognosis.
Study context
- Population
- Patients admitted to the Hospital Vila Franca de Xira ICU for >24 h, 2015–2023, without kidney dysfunction on admission
- Participants
- 1,157 patients
- Exposure
- NSAID use vs no NSAID use
- Outcome
- AKI (serum creatinine and urine output) during ICU and hospital stay
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
AKI
Nonsteroidal anti-inflammatory drugs (NSAIDs)
67.
No NSAIDs
51.
P = 0.009
Observational data: associations, not effects.
Further findings
2-year survival, severe acute kidney injury (AKI)
| aHR for death (worse survival) (CI) | P value | ||
|---|---|---|---|
| Severe AKI | 1.42 (1.09–1.86) | P = 0.011 | |
| 0.512AHR for death (worse survival) (log scale) |
| Outcome | Non-scheduled surgery | Scheduled surgery | Medical | P value |
|---|---|---|---|---|
| NSAID use by admission typeSurgical vs Medical | 62. | 61. | 23. | P < 0.001 |
| Severe AKI (stage 3)NSAID vs No NSAID | P = 0.008 | |||
| Long-term survival by recovery of renal functionLog-rank test; 80. vs. 78. · log-rank test | P = 0.636 |
2-year survival, severe AKI
- Non-severe AKI had no significant impact on 2-year survival
Long-term survival by recovery of renal function
- Recovery of renal function did not significantly decrease long-term survival
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Incidence of kidney toxicity of non-steroidal anti-inflammatory drugs in critically ill patients. J Crit Care. Published 23 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →