Pediatric anesthesia & critical care
The efficacy of magnesium sulphate in preventing laryngospasm in paediatric patients undergoing general anaesthesia: A systematic review and meta-analysis of randomised control trials
Pooled result · Pooled dataResult — go to the resultOdds ratio 0.48 95% CI 0.25–0.96Authors' conclusion
This review shows a potential role for magnesium in the prevention of laryngospasm in paediatric patients undergoing general anaesthesia. There is a correlation between local administration of magnesium and reduction in laryngospasm rates.
Study context
- Population
- Paediatric patients undergoing GA (excluding CPB)
- Participants
- 953 patients · 13 trials
- Comparison
- Magnesium vs Control
- Outcome
- Incidence of laryngospasm
Methodological detailssubgroup analysis
- Subgroup analysis
Pooled result
Pooled data
Odds ratio
0.48
95% CI 0.25–0.96
P = 0.04
Magnesium vs Control
OR 0.48 (95% CI 0.25–0.96); P = 0.04
As reported in the abstract
Further pooled results
| Outcome | OR | P value | |
|---|---|---|---|
| Laryngospasm (subgroup: local magnesium)Rates lower by 12.5%; 4 RCTs local | 0.26 (CI 0.09–0.76) | P = 0.01 | |
| Laryngospasm (subgroup: IV magnesium)9 RCTs IV | 0.73 (95% CI 0.33–1.63) | P = 0.44 | |
| 0.050.21520Odds ratio (log scale) |
Original publication
The efficacy of magnesium sulphate in preventing laryngospasm in paediatric patients undergoing general anaesthesia: A systematic review and meta-analysis of randomised control trials. Anaesth Crit Care Pain Med. Published 30 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →