Pediatric anesthesia & critical care
Intravenous lidocaine for postoperative analgesia management in paediatrics: A systematic review with meta-analysis of published studies
Pooled result · Pain intensity in PACUResult — go to the resultSMD −1.89 CI −3.75 to −0.03Authors' conclusion
The use of lidocaine is associated with improved pain management.
Study context
- Population
- Paediatric surgical patients
- Comparison
- IV lidocaine vs placebo
- Outcome
- Postoperative pain intensity and opioid consumption
Methodological detailsGrading of Recommendations Assessment, Development and Evaluation (GRADE) analysis
- GRADE analysis
Pooled result
Pain intensity in PACU
SMD
−1.89
CI −3.75 to −0.03
Lidocaine vs Placebo
SMD −1.89 (CI −3.75 to −0.03)
As reported in the abstract
Further pooled results
| Outcome | SMD (CI) | |
|---|---|---|
| Pain intensity on POD 1 · postoperative day 1I2 = 96%, P of I2 < 0.001 | −2.02 (−3.37 to −0.66) | |
| Opioid consumption on POD 1 · postoperative day 1I2 = 93%, P of I2 < 0.001 | −1.2 (−2.19 to −0.2) | |
| Opioid consumption on POD 2 · postoperative day 2I2 = 96%, P of I2 < 0.001 | −1.73 (−3.9 to 0.44) | |
| −4−202Difference (linear scale) |
- Pain intensity on POD 1: 5 studies
Opioid consumption on POD 2 · postoperative day 2
- No decrease in opioid consumption on POD 2
Pain intensity in PACU and opioid consumption on POD 1 by administration period (subgroup)
- Decreased when lidocaine was given during both the intra-operative and postoperative periods
Original publication
Intravenous lidocaine for postoperative analgesia management in paediatrics: A systematic review with meta-analysis of published studies. Eur J Anaesthesiol. Published 29 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →