Efficacy of Cryoneurolysis on Chronic Pain in Patients with Knee Osteoarthritis: A Double-blinded Randomized Controlled Sham Trial
Authors' conclusion
This study did not show a clinically relevant reduction in pain after intervention comparing cryoneurolysis and sham.
Study context
- Population
- Patients with chronic knee osteoarthritis
- Participants
- 87 patients
- Comparison
- Cryoneurolysis vs sham procedure, both followed by an exercise program
- Primary endpoint
- Difference in average pain between cryoneurolysis and sham
- Follow-up
- 14 days after intervention
Methodological detailsdouble-blind, sham-controlled
- Double-blind
- Sham-controlled
Primary result
As reported in the abstract
Average pain
Cryoneurolysis
−1.9
95% CI −2.4–-1.3
Sham
−1.4
95% CI −1.9–-0.8
- No difference for the primary outcome
- 0.49 (difference in average pain at 14 days; 95% CI, −0.3 to 1.2; P = 0.198)
Further findings
| Outcome | Difference (95% CI) | P value | |
|---|---|---|---|
| Pain · 6 monthsSignificant reduction in cryoneurolysis vs sham | 1.1 (0.3–1.9) | P = 0.009 | |
| −1012Difference (linear scale) |
Change in pain scores from baseline · 14 days after intervention
- Significant pain reduction in both groups
Original publication
Efficacy of Cryoneurolysis on Chronic Pain in Patients with Knee Osteoarthritis: A Double-blinded Randomized Controlled Sham Trial. Anesthesiology. Published 30 January 2025. doi:10.
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