Efficacy of Simple Oral Nutritional Supplements versus Usual Care in Postoperative Patients with Gastric Cancer: A Multicenter, Open-label, Parallel, Randomized Controlled Trial
Authors' conclusion
The simple ONS for 8 weeks after gastrectomy reduced postoperative BWL in patients with gastric cancer.
Study context
- Population
- Patients undergoing curative gastrectomy for gastric cancer, 19 institutions2 oral nutritional supplement (ONS) lost to follow-up
- Participants
- 124 patients
- Comparison
- Simple ONS vs usual care
- ONSn = 62
- Controln = 62reference
- Primary endpoint
- Percentage of body weight loss (BWL) from baseline
- Follow-up
- Postoperative 8 weeks
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
ONS
−4.8%
Control
−6.4%
P = 0.039
Secondary outcomes
- ONS adherence (mean intake)
- 308.7 · mean · SD 97.0 · mL/d
- ONS adherence (mean intake): >75%
Handgrip strength and hematological parameters
- No significant differences
Safety
Adverse events · comparable
P = 0.373
Symptom scores for insomnia, appetite loss, diarrhea during intervention
- Higher in the ONS group
Original publication
Efficacy of Simple Oral Nutritional Supplements versus Usual Care in Postoperative Patients with Gastric Cancer: A Multicenter, Open-label, Parallel, Randomized Controlled Trial. Ann Surg. Published 7 August 2025. doi:10.
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