Neuroanesthesia & neurocritical care
Electroencephalography for prognostication of outcome in adults with severe herpes simplex encephalitis
Authors' conclusion
Absence of EEG reactivity to auditory/noxious stimuli is an independent marker of poor functional outcome in severe herpes simplex encephalitis.
Study context
- Population
- Adult ICU patients with severe herpes simplex encephalitis with ≥1 standard EEG at ICU admission, 38 French centres, 2006–2016
- Participants
- 214 patients
- Exposure
- Standard EEG findings vs poor functional outcome
- Outcome
- Poor functional outcome:
- Modified Rankin Scale 3 to 6: moderate to severe disability
- Death
- Follow-up
- 90 days
Methodological detailsmulticentre, consecutive patients, stdEEG findings reviewed independently by two investigators
- Multicentre
- Consecutive patients
- stdEEG findings reviewed independently by two investigators
Main finding
As reported in the abstract
Poor functional outcome (modified Rankin Scale (mRS) 3 to 6) at 90 days, by absence of stdEEG reactivity
Absence of reactivityOdds ratio (95% CI)
Whole population
2.80(1.19–6.58)
Subgroup of mechanically ventilated patients
4.99(1.6–15.59)
Observational data: associations, not effects.
Further findings
Poor functional outcome, absence of reactivity, adjusted for common clinical predictors and sedation at time of stdEEG · 90 days
| OR (95% CI) | ||
|---|---|---|
| Whole populationAdjusted analysis | 2.03 (1.18–3.49) | |
| Mechanically ventilated patientsAdjusted analysis | 2.62 (1.25–5.50) | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Electroencephalography for prognostication of outcome in adults with severe herpes simplex encephalitis. Ann Intensive Care. Published 23 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →