Cardiac arrest & resuscitation
Elevated glycocalyx shedding components as the early predictors of unfavorable outcomes in patients after cardiac arrest: A single-center observational study
Main finding · Serum HA, 30-day neurological outcomeResult — go to the resultOdds ratio 2.485 95 % CI 1.656–3.729Authors' conclusion
Elevated serum HA at 24 h after CA is an independent risk factor for 30-day unfavorable neurological function or mortality and elevated serum Sdc-1 concentrations is an independent risk factor for 30-day mortality.
Study context
- Population
- Patients comatose >24 h after CA in the Intensive Care Unit (ICU) of the Affiliated Hospital of Xuzhou Medical University, 9/2021 to 04/2023
- Participants
- 111 participants
- Exposure
- Serum glycocalyx shedding components (HA, HS, Sdc-1) 24 h after CA in unfavorable vs favorable outcome and nonsurvivors vs survivors
- Favorablen = 42reference
- Unfavorablen = 69
- Survivorn = 58reference
- Nonsurvivorn = 53
- Outcome
- Cerebral Performance Categories (CPC) scale and mortality
- Follow-up
- 30 days
Methodological detailssingle-centre
- Single-centre
Main finding
Serum HA, 30-day neurological outcome
Odds ratio
2.485
95 % CI 1.656–3.729
By group
Elevated serum HA
OR 2.485 (95 % CI 1.656–3.729)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Serum HA, 30-day mortality
| HR (95 % CI) | ||
|---|---|---|
| Elevated serum HAIndependent risk factor for 30-day mortality | 2.321 (1.776–3.035) | |
| 0.20.5125Hazard ratio (log scale) |
Serum Sdc-1, 30-day mortality
| HR (95 % CI) | ||
|---|---|---|
| Elevated serum Sdc-1Independent risk factor for 30-day mortality | 1.702 (1.038–2.792) | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | Favorable | Unfavorable | Survivor | Nonsurvivor | P value |
|---|---|---|---|---|---|
| Serum Sdc-1, 30-day neurological outcome · 30 daysUnfavorable vs Favorable | 303.8 ng/L | 447.0 ng/L | — not stated in the abstract | — not stated in the abstract | P = 0.026 |
| Serum HA, 30-day mortality · 30 daysNonsurvivor vs Survivor | — not stated in the abstract | — not stated in the abstract | 177.3 ng/ml | 1106.7 ng/ml | P < 0.001 |
| Serum HS, 30-day mortality · 30 daysNonsurvivor vs Survivor · not an independent risk factor | — not stated in the abstract | — not stated in the abstract | 2403.7 ng/ml | 3383.3 ng/ml | P = 0.030 |
| Serum Sdc-1, 30-day mortality · 30 daysNonsurvivor vs Survivor | — not stated in the abstract | — not stated in the abstract | 352.1 ng/L | 487.8 ng/L | P = 0.005 |
— not stated in the abstract
Serum HS, 30-day neurological outcome
- HS not significantly higher in the unfavorable group
Original publication
Elevated glycocalyx shedding components as the early predictors of unfavorable outcomes in patients after cardiac arrest: A single-center observational study. J Crit Care. Published 24 January 2025. doi:10.
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