Respiratory failure & ventilation
Elevated MMP-8 levels, inversely associated with body mass index (BMI), predict mortality in mechanically ventilated patients: an observational multicenter study
Authors' conclusion
This study provides evidence for a protective effect of obesity in mechanically ventilated patients and highlights the potential role of MMP-8 level as a biomarker for predicting mortality risk in this population.
Study context
- Population
- Critically ill patients receiving mechanical ventilation, 3 medical centresretrospective
- Participants
- 3,301 patients
- Exposure
- Weight categories; high vs low MMP-8 levels
- Outcome
- Mortality across weight categories
Methodological detailsretrospective analysis, machine learning, bioinformatics analysis, prospective validation cohort, enzyme-linked immunosorbent assay (ELISA), 50 healthy individuals as additional prospective comparison cohort
- Retrospective analysis
- Machine learning
- Bioinformatics analysis
- Prospective validation cohort
- ELISA
- 50 healthy individuals as additional prospective comparison cohort
Main finding
As reported in the abstract
Mortality
- Overweight individuals had lower mortality than underweight individuals
- BMI an independent protective factor
- Retrospective analysis
Observational data: associations, not effects.
Further findings
| Outcome | OR | P value |
|---|---|---|
| Mortality risk with high MMP-8 levels (prospective cohort) | 4.249 | P = 0.005 |
- MMP-8 levels, overweight vs underweight (prospective cohort) — MMP-8 levels as printed · significantly lower MMP-8 levels in overweight patients
- 3.717 (2.628, 4.191) vs. 2.763 (1.923, 3.753), ng/ml · P = 0.002
Original publication
Elevated MMP-8 levels, inversely associated with BMI, predict mortality in mechanically ventilated patients: an observational multicenter study. Crit Care. Published 18 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →