ICU sedation, delirium & recovery
Emergency Department Triage, Transfer Times, and Hospital Mortality of Patients Admitted to the ICU: A Retrospective Replication and Continuation Study*
Main finding · Hospital mortality by ED-to-ICU timeResult — go to the resultAdjusted odds ratio 1.24 95% CI 1.00–1.54Authors' conclusion
In patients with the highest APACHE-IV probability at academic hospitals, a prolonged ED-to-ICU time was associated with increased hospital mortality.
Study context
- Population
- Patients directly admitted from the emergency department (ED) to the ICU at four academic and eight nonacademic teaching (NACT) hospitals, Dutch National Intensive Care Evaluation registry, 2009–2020four academic, eight NACT hospitals
- Participants
- 28,455 participants
- Exposure
- Longer vs shorter ED-to-ICU time
- Outcome
- Hospital mortality by ED-to-ICU time
Methodological detailsmulticentre registry, replication and continuation study
- Multicentre registry
- Replication and continuation study
Main finding
As reported in the abstract
Adjusted odds ratio
1.24
95% CI 1.00–1.54
P < 0.05
> 3.4 hr vs < 1.1 hr
aOR 1.24 (95% CI 1.00–1.54); P < 0.05
- No overall association between ED-to-ICU time and hospital mortality after adjusting for APACHE-IV probability
- P = 0.36
Observational data: associations, not effects.
Further findings
| Outcome | OR adjApache | P value | |
|---|---|---|---|
| Hospital mortality, APACHE-IV probability >55.4% (highest quintile) (subgroup)>3.4 hr vs <1.1 hr · adjusted for APACHE-IV probability | 1.24 (95% CI 1.00–1.54) | P < 0.05 | |
| Hospital mortality, academic hospitals (subgroup)1.6-2.3 hr vs <1.1 hr · adjusted for APACHE-IV probability | 1.21 (CI 1.01–1.46) | ||
| Hospital mortality, academic hospitals (subgroup)2.3-3.4 hr vs <1.1 hr · adjusted for APACHE-IV probability | 1.21 (CI 1.00–1.46) | ||
| Hospital mortality, academic hospitals (subgroup)>3.4 hr vs <1.1 hr · adjusted for APACHE-IV probability | 1.34 (CI 1.10–1.64) | ||
| 0.512OR adjApache (log scale) |
ED-to-ICU time
- Median ED-to-ICU time (IQR 1.2-3.1 hr)
- 1.9 hours
Hospital mortality, NACT hospitals (subgroup)
- No association observed (adjusted for APACHE-IV probability)
- P = 0.07
Hospital mortality, academic hospitals, adjusted for ED-triage score (subgroup)
- No overall association
- P = 0.08
Hospital mortality, NACT hospitals, adjusted for ED-triage score (subgroup)
- All time-ascending quintiles had odds ratios (ORs) adjED <1.0
- P < 0.01
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Emergency Department Triage, Transfer Times, and Hospital Mortality of Patients Admitted to the ICU: A Retrospective Replication and Continuation Study*. Crit Care Med. Published 19 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →